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Rheumatology 2003; 42: II3-II10
© 2003 British Society for Rheumatology

Original Article

The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis

J.-M. Dayer

University Hospital, Geneva, Switzerland.

Correspondence to: Correspondence to: J.-M. Dayer, Division of Immunology and Allergy, University Hospital, 1211 Geneva 14, Switzerland. E-mail: jean-michel.dayer{at}hcuge.ch

The role of the cytokine network in mediating inflammation and joint destruction in rheumatoid arthritis (RA) has been investigated extensively in recent years. Interleukin-1 (IL-1) and tumour necrosis factor alpha (TNF{alpha}) are two pivotal proinflammatory cytokines that have been shown to contribute to the clinical manifestations of RA. The ability of IL-1 to drive inflammation and joint erosion and to inhibit tissue repair processes has been clearly established in in vitro systems and animal models. Under physiological conditions, the activity of IL-1 is balanced by IL-1 receptor antagonist (IL-1Ra). Understanding of the respective roles of IL-1 and IL-1Ra in conditions of health and disease has led to the development of a recombinant IL-1ra, anakinra (Kineret®; Amgen Inc., Thousand Oaks, CA), which offers a new therapeutic modality for RA.

KEY WORDS: Bone, Cartilage, Inflammation, Interleukin-1, Interleukin-1 receptor antagonist, Rheumatoid arthritis, Tumour necrosis factor alpha


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