Rheumatology Advance Access originally published online on October 17, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rheumatology 2004; 43: 13-18
© British Society for Rheumatology 2003; all rights reserved
Review |
Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine
Rheumatology Department, Ipswich Hospital NHS Trust, Ipswich and University of Sheffield, Division of Clinical Sciences (South), Section Medicine & Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.
Correspondence to: G. P. R. Clunie, Rheumatology Department, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk IP4 5PD, UK. E-mail: gavin.clunie{at}doctors.org.uk
Azathioprine (AZA) is widely used in the management of rheumatological diseases. Despite its efficacy, AZA can often cause bone marrow suppression, notably leucopenia, which has been recorded in up to 17% of patients taking AZA for rheumatoid arthritis, though this can be considered clinically significant in about 3% overall. Severe myelosuppression, associated with abnormal AZA metabolism, is linked to the thiopurine methyltransferase (TPMT) genetic polymorphism. TPMT status can be assessed prior to AZA treatment by measuring enzyme activity or genotyping techniques. Analysis of recent data suggests that by optimizing the AZA dose on the basis of TPMT status testing (with a substantial reduction in dose for patients homozygous for mutant TPMT alleles), a reduction in drug-induced morbidity and cost savings can be made by avoiding hospitalization and rescue therapy for leucopenic events. In this article we review the pharmacogenetic and clinical implications of the TPMT polymorphism, emphasizing its relevance to rheumatologists managing diseases with AZA.
KEY WORDS: Myelosuppression, Thiopurine methyltransferase (TPMT), Azathioprine, Mercaptopurine.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. A. Bakker, J. Bierau, and M. Drent Therapeutic regimens in interstitial lung disease guided by genetic screening: fact or fiction? Eur. Respir. J., November 1, 2007; 30(5): 821 - 822. [Full Text] [PDF]
|
|
|
|
 |
|
 V Gauba, M Saldanha, C Vize, and G M Saleh Thiopurine methyltransferase screening before azathioprine therapy Br J Ophthalmol, July 1, 2006; 90(7): 923 - 924. [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Marshall, V. J. Marshall, and R. Hull Disease-modifying anti-rheumatic drugs are only one of a number of potential causes of myelosuppression: a careful drug history is necessary to elucidate the cause of an adverse event Rheumatology, March 1, 2006; 45(3): 362 - 363. [Full Text] [PDF]
|
|
|
|
 |
|
 E M Frohman, E Havrdova, B Levinson, and O Slanar Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms Multiple Sclerosis, February 1, 2006; 12(1): 108 - 111. [Abstract] [PDF]
|
|