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Rheumatology Advance Access originally published online on September 16, 2003
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Rheumatology 2004; 43: 238-240
© British Society for Rheumatology 2003; all rights reserved

Clinical

Type 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients

A. Antonelli, C. Ferri1, P. Fallahi, M. Sebastiani, C. Nesti, L. Barani, R. Barale2 and E. Ferrannini

Department of Internal Medicine, University of Pisa School of Medicine, Pisa, 1Rheumatology Unit, University of Modena, Modena and 2Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy.

Correspondence to: A. Antonelli, Department of Internal Medicine, University of Pisa, via Roma, 67, 56100, Pisa, Italy. E-mail: a.antonelli{at}med.unipi.it

Objectives. Mixed cryoglobulinaemia (MC) is a systemic vasculitis frequently associated with hepatitis C virus (HCV) infection. A possible link between HCV infection and type 2 diabetes has been suggested. This study evaluated the prevalence and clinical phenotype of diabetes in MC-HCV+ patients.

Methods. Two hundred and twenty-nine consecutively recruited MC-HCV+ patients were compared with 217 sex- and age-matched controls without HCV infection.

Results. The prevalence of type 2 diabetes was significantly higher in MC-HCV+ patients than in controls (14.4 vs 6.9%, P < 0.01). Diabetic MC-HCV+ patients were leaner than diabetic patients without MC-HCV (P < 0.0001), and showed significantly lower total and low-density lipoprotein cholesterol levels (P < 0.001) and lower systolic (P = 0.01) and diastolic blood pressure (P = 0.005). MC-HCV+ diabetic patients had non-organ-specific autoantibodies more frequently (34 vs 18%, P = 0.032) than non-diabetic MC-HCV+ patients.

Conclusions. The prevalence of type 2 diabetes is higher in patients with MC-HCV than in controls. Diabetic MC-HCV+ patients show an attenuated diabetic phenotype and are more likely to carry non-organ-specific autoantibodies.

KEY WORDS: Mixed cryoglobulinaemia, HCV, Type II diabetes, BMI, LDL cholesterol, Non-organ-specific autoantibodies.


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