Rheumatology Advance Access originally published online on January 6, 2004
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Rheumatology 2004; 43: 428-434
Rheumatology Vol. 43 No. 4 (c) British Society for Rheumatology 2004; all rights reserved
Basic Science |
Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP
Rheumatology Unit, Department of Medicine, Karolinska Hospital, Stockholm, 1Department of Clinical Chemistry, University Hospital, Uppsala and 2Department of Rheumatology and Department of Cell and Molecular Biology, Lund University, Lund, Sweden
Correspondence to: E. Larsson, Rheumatology Unit, Department of Medicine, Karolinska Hospital, S-171 76 Stockholm, Sweden. E-mail: esbjorn.larsson{at}ks.se
Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA).
Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once daily after reaching an arthritis score exceeding 1. The treatment continued throughout the study. Arthritis progression was monitored by clinical scoring of paws, serial measurements of serum COMP and fibrinogen, and histological grading of paws.
Results. Corticosteroid treatment reduced clinical signs of arthritis compared with placebo (arthritis score reduced, P < 0.01 at day 25). Corticosteroid treatment also reduced fibrinogen levels compared with placebo (P < 0.01). The morphological changes in the joint were less severe in the corticosteroid-treated animals (median cartilage score 4 in the placebo group, 0 in the corticosteroid-treated group; P < 0.01). The levels of COMP remained unchanged during treatment in the corticosteroid-treated arthritic animals, whereas an increase in levels of COMP was observed in rats treated with placebo (P < 0.01). There was a correlation between serum COMP and the extent of cartilage destruction at day 25 after immunization (r = 0.77, P < 0.001).
Conclusions. Corticosteroids given therapeutically to arthritic rats diminish joint destruction histologically, and stable serum COMP levels reflect this effect.
KEY WORDS: Collagen-induced arthritis, Cartilage oligomeric matrix protein (COMP), Fibrinogen, Corticosteroids.
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