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Rheumatology Advance Access originally published online on April 27, 2004
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Rheumatology 2004; 43: 839-842
Rheumatology Vol. 43 No. 7 © British Society for Rheumatology 2004; all rights reserved

Paper

HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients

J. C. C. Wei, W. C. Tsai1, H. S. Lin2, C. Y. Tsai3 and C. T. Chou3

Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine and Institute of Medicine, Chung Shan Medical University, Taichung, 1 Department of Medicine, Kaohsiung Medical University Hospital, 2 Department of Nursing Management, Fooyin University, Kaohsiung and 3 Division of Allergy-Immunology-Rheumatology, Veterans General Hospital, Taipei, Taiwan.

Correspondence to: C. T. Chou, Division of Allergy-Immunology-Rheumatology, Veterans General Hospital-Taipei, No. 201, Sec. 2, Shpai Road, Beitou Chiu, Taipei, Taiwan 112. E-mail: ctchou{at}vghtpe.gov.tw

Objectives. Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients.

Methods. Forty-one Chinese HLA-B27-negative AS patients fulfilling the modified New York diagnostic criteria for AS were recruited, and 11 383 HLA-B27-negative blood donors were used for comparison. HLA-A and -B typing was done with the microlymphocytotoxicity assay.

Results. Among the B27-negative AS patients, 21 were male and 20 were female. Of HLA-B alleles, only B60 and B61 significantly increased susceptibility to AS in HLA-B27-negative patients (P<0.001).

Conclusions. In Taiwan Chinese, carriage of B60 is increased in HLA-B27-negative AS patients. The association between B61 and HLA-B27-negative AS patients has not been reported previously. Whether the gene involved is HLA-B60 or B61 or another gene in linkage disequilibrium with these genes is unknown.

KEY WORDS: Ankylosing spondylitis, HLA-B27-negative, HLA-class I genes


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