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Rheumatology Advance Access originally published online on May 31, 2005
Rheumatology 2005 44(10):1217-1226; doi:10.1093/rheumatology/keh694
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

REVIEW

Rheumatology: a close encounter with proteomics

K. Tilleman, D. Deforce and D. Elewaut1

Laboratory of Pharmaceutical Biotechnology, Ghent University and 1 Laboratory for Molecular Immunology and Inflammation, Division of Rheumatology, Ghent University Hospital, Ghent, Belgium.

Correspondence to: Dirk Elewaut, Laboratory for Molecular Immunology and Inflammation, Division of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium, E-mail: Dirk.Elewaut{at}Ugent.be, or Dieter Deforce, Laboratory of Pharmaceutical Biotechnology, Harelbekestraat 72, 9000 Ghent, Belgium, E-mail: Dieter.Deforce{at}Ugent.be

Proteomics is a fast-growing discipline in biomedicine that can be defined as the large-scale characterization of the entire protein complement of a cell, tissue or organism. Because protein levels and function may be critically dependent upon post-transcriptional mechanisms (e.g. post-translational modifications), there has been significant interest in directly examining protein structure and function. It is now clear that proteomics studies may unmask previously unknown functions of proteins or protein interactions. However, proteomics in the field of rheumatology is still in its infancy. This review guides the reader through the consecutive steps of a proteomics study and provides an outline of the applications in the field of rheumatology, which may range from proteome analyses of biological fluids of rheumatic diseases to identify possible new diagnostic tools, towards more pathophysiological studies on target tissues, such as synovial tissue or articular cartilage. Proteomics has great potential in the field of rheumatology and will no doubt have a great impact on our molecular understanding of these complex diseases.

KEY WORDS: Proteomics, Two-dimensional gel electrophoresis, Mass spectrometry, Rheumatology, Autoimmunity


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