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Rheumatology Advance Access originally published online on June 21, 2005
Rheumatology 2005 44(10):1227-1232; doi:10.1093/rheumatology/keh719
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

REVIEW

Complement and its breakdown products in SLE

G. Sturfelt and L. Truedsson1

Department of Rheumatology and 1 Department of Clinical Microbiology and Immunology, University Hospital of Lund, Lund, Sweden.

Correspondence to: G. Sturfelt, Department of Rheumatology, University Hospital of Lund, SE-22185 Lund, Sweden. E-mail: Gunnar.Sturfelt{at}reum.lu.se

The complement system has important protective functions in both the innate and the adaptive immune systems but can also, when inappropriately activated, cause tissue damage. Complement deficiency predisposes to infection and also to development of autoimmune disease, especially SLE, and complement is at the same time involved in the pathogenesis of this disease. In this review, various aspects of this dualism are discussed. An overview of activation pathways and activation products is given, together with a description of autoimmunity against complement and the potential of complement regulation in future therapeutics.

KEY WORDS: Complement, SLE


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