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Rheumatology Advance Access originally published online on June 7, 2005
Rheumatology 2005 44(9):1136-1139; doi:10.1093/rheumatology/keh697
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus

E. Sánchez, S. Morales, L. Paco1, M. A. López-Nevot1, C. Hidalgo2, J. Jiménez-Alonso2, B. Torres3, M. A. González-Gay4, J. L. Callejas5, N. Ortego-Centeno5, J. Sánchez-Roman6, M. F. González-Escribano3 and J. Martín

Instituto de Parasitología y Biomedicina López-Neyra, CSIC, 1 Servicio de Inmunología and 2 Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, 3 Servicio de Inmunología, Hospital Virgen del Rocío, Seville, 4 Servicio de Reumatología, Hospital Xeral-Calde, Lugo, 5 Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada and 6 Servicio de Medicina Interna, Hospital Virgen del Rocío, Seville, Spain.

Correspondence to: J. Martín, Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n 18100-Armilla (Granada), Spain. E-mail: martin{at}ipb.csic.es

Objective. The aim of this study was to assess the possible association between the interleukin-12B (IL12B) and interleukin-12 receptor beta 1 (IL12RB1) gene polymorphisms with systemic lupus erythematosus (SLE). In addition, we have undertaken a systematic search for genetic variants of interleukin 23 (IL23A).

Methods. The study was conducted on 559 SLE patients and 603 ethnically matched healthy controls. Genotyping of the IL12B [IL12Bpro and IL12B 3' untranslated region (UTR)] and IL12RB1 (641A->G, 1094T->C and 1132G->C) polymorphisms was performed with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR-fluorescent methods, whereas IL23A genetic variants were realized with direct sequencing.

Results. No statistically significant differences in the distribution of the IL12B and the IL12RB1 genotypes and alleles were observed when comparing SLE patients and control subjects. Additionally, no differences in the genotype and allele distribution were found when SLE patients were stratified according to the presence or absence of lupus nephritis. Despite an extensive analysis in 30 individuals, variations located in the exons and in the 5' and 3' UTR regions of IL23A gene were not found in any case.

Conclusions. These results suggest that polymorphisms located in IL12B, IL12RB1 and IL23A genes may not play a relevant role in the susceptibility or severity of SLE in the Spanish population.

KEY WORDS: Systemic lupus erythematosus (SLE), Interleukin-12 (IL-12), Interleukin-12 receptor (IL-12R), Interleukin-23 (IL-23), Polymorphism, Susceptibility


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