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Rheumatology 2005 44(Supplement 3):iii9; doi:10.1093/rheumatology/keh744
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Supplement Article

OP19. ENDOTHELIAL CELL PATHOBIOLOGY

A. Hingorani

Royal Free and University College Medical School, University College London, UK

Associations exist between acute and chronic inflammatory exposures and cardiovascular events. Acute infection or surgery are associated with a transient increase in the risk of stroke and myocardial infarction, and a number of autoimmune and chronic inflammatory disorders are associated with an increase in such risk over the longer term, though a causal link has yet to be proven in humans. Products of the inflammatory response have effects on the vascular endothelium that might attenuate its normal atheroprotective functions, and could provide a mechanistic link between inflammation and cardiovascular disease. Whether interventions to modify the inflammatory response would be efficacious in reducing cardiovascular events in acute or chronic settings is yet uncertain.


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