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Rheumatology Advance Access originally published online on September 7, 2005
Rheumatology 2006 45(1):11-19; doi:10.1093/rheumatology/kei091
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REVIEW

The pathophysiology of the growth plate in juvenile idiopathic arthritis

V. E. MacRae1,2, C. Farquharson1 and S. F. Ahmed2

1 Bone Biology Group, Division of Gene Function and Development, Roslin Institute, Edinburgh and 2 Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow, UK.

Correspondence to: S. F. Ahmed, Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK. E-mail: gcl328{at}clinmed.gla.ac.uk

Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general growth retardation to local acceleration of growth in the affected limb. These disorders are associated with the increased production of proinflammatory cytokines, which may influence growth through a local effect in the growth plates of long bones and/or systemic effects throughout the whole body. In this article we review these aspects and also discuss the evidence for interaction between the inflammatory cytokine and growth-signalling pathways.


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