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Rheumatology 2006 45(Supplement 4):iv8-iv13; doi:10.1093/rheumatology/kel308
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus

A. Tincani, C. B. Rebaioli, M. Taglietti and Y. Shoenfeld1

Reumatologia e Immunologia Clinica, Ospedale Civile e Università di Brescia, Italy and 1Department Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv University, Tel-Hashomer, Israel.

Correspondence to: Angela Tincani, MD, Reumatologia e Immunologia Clinica, Ospedale Civile, Piazza Spedali Civili 1, 25125 Brescia, Italy. E-mail: tincani{at}bresciareumatologia.it

Cardiac involvement is one of the main complications substantially contributing to the morbidity and mortality of patients suffering from systemic autoimmune diseases. All the anatomical heart structures can be affected, and multiple pathogenic mechanisms have been reported. Non-organ-specific autoantibodies have been implicated in immune complex formation and deposition as the initial triggers for inflammatory processes responsible for Libman–Sacks verrucous endocarditis, myocarditis and pericarditis. Anti-phospholipid antibodies have been associated with thrombotic events in coronary arteries, heart valve involvement and intra-myocardial vasculopathy in the context of primary and secondary anti-phospholipid syndrome. Antibodies-SSA/Ro and anti-SSB/La antigens play a major pathogenic role in affecting the heart conduction tissue leading to the electrocardiographic abnormalities of the neonatal lupus syndrome and have been closely associated with endocardial fibroelastosis.


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