Skip Navigation


Rheumatology Advance Access originally published online on August 5, 2006
Rheumatology 2007 46(2):246-249; doi:10.1093/rheumatology/kel263
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
46/2/246    most recent
kel263v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Rothschild, B. M.
Right arrow Articles by Panza, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rothschild, B. M.
Right arrow Articles by Panza, R. K.
Related Collections
Right arrow Osteoarthritis and Cartilage
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lack of bone stiffness/strength contribution to osteoarthritis—evidence for primary role of cartilage damage

B. M. Rothschild1–4 and R. K. Panza3,*

1Arthritis Center of Northeast Ohio, 5500 Market, Youngstown, OH 44512, 2Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44512, 3Carnegie Museum of Natural History, 4400 Forbes Ave, Pittsburgh, PA 15213 and 4Dyche Hall, University of Kansas Museum of Natural History, Lawrence, KS 66044, USA.

Correspondence to: Bruce M. Rothschild, Arthritis Center of Northeast Ohio, 5500 Market Street, Youngstown, OH 44512, USA. E-mail: bmr{at}neoucom.edu


  Abstract

Objectives. This study was performed to assess osseous contributions to osteoarthritis, obviating the analysis challenges presented by confounding factors in humans and rarity of osteoarthritis in free-ranging mammals.

Methods. Frequency of osteoarthritis in 21 bird species was examined and contrasted with measures of afflicted element bone stiffness and strength and compression/tension-resistant characteristics.

Results. Osteoarthritis was present in the ankle of 0–16% of bird species analysed, independent of bone laminarity, cortical thickness, circularity, polarization, cross-sectional diameter, length and pneumatization.

Conclusions. No correlation of frequency of osteoarthritis with parameters of bone strength and biomechanical parameters was found, suggesting that bone is only secondarily affected in osteoarthritis and that cartilage is the initial target of the disease.

KEY WORDS: Osteoarthritis, Animal model

*The corresponding author verifies that the co-author has contributed to the work but that the author is non-contactable.

Submitted 31 January 2006; revised version accepted 27 June 2006.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.