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Rheumatology Advance Access originally published online on August 5, 2006
Rheumatology 2007 46(2):250-252; doi:10.1093/rheumatology/kel265
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus

S. Snelling, J. S. Sinsheimer1, A. Carr and J. Loughlin

University of Oxford, Nuffield Department of Orthopaedic Surgery, Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK and 1Departments of Human Genetics and Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1766, USA

Correspondence to: Sarah Snelling, University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK. E-mail: sarah.snelling{at}ndos.ox.ac.uk


  Abstract

Objective. A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample and confirmed in a Newfoundland Caucasian sample. Our objective was to assess whether the SNP was associated with OA in our large UK Caucasian sample.

Methods. The SNP was genotyped in 1521 cases that had undergone elective joint replacement of the hip (1098 cases), of the knee (340 cases) or of the hip and knee (83 cases) due to end-stage primary OA. The SNP was also genotyped in 736 controls of similar ages in the cases.

Results. There was no significant difference (all P-values >0.05) in genotype or allele frequencies between our cases and our controls. There was also no significant difference when the cases were stratified by sex, by joint replaced or by sex combined with joint replaced.

Conclusion. Our data on 2257 individuals implies that the LRCH1 intron 1 SNP is not a risk factor for OA aetiology of the knee or of the hip in our UK Caucasian sample.

KEY WORDS: Osteoarthritis, LRCH1, Genetic susceptibility, SNP

Submitted 3 May 2006; revised version accepted 27 June 2006.
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