Rheumatology Advance Access originally published online on July 28, 2006
Rheumatology 2007 46(2):296-301; doi:10.1093/rheumatology/kel221
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Validity of the Saint George's Respiratory Questionnaire in the evaluation of the health-related quality of life in patients with interstitial lung disease secondary to systemic sclerosis
Centro di Riferimento per le Malattie Autoimmuni Sistemiche and 1Dipartimento di Radiologia, Fondazione IRCCS, Policlinico-Mangaigalli-Regina Elena, Italy
Correspondence to: Dr Lorenzo Beretta, Clinical Immunology Unit, Fondazione IRCCS, Policlinico-Mangaigalli-Regina Elena, Ospedale Maggiore di Milano, 20122, Via Pace 9, Milano, Italy. E-mail: lorberimm{at}hotmail.com
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Abstract |
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Objectives. Interstitial lung disease (ILD) profoundly affects the health-related quality of life (HRQoL) in patients with systemic sclerosis (SSc). We tested the validity of the Saint George's Respiratory Questionnaire (SGRQ), a lung-specific HRQoL-evaluation tool, in a population of SSc patients with ILD.
Methods. Twenty-eight consecutive SSc patients with a restrictive pulmonary involvement, defined as a forced vital capacity <80% of the predicted, with no pulmonary hypertension were considered. All the patients filled in the Medical Research Council (MRC) scale for perceived breathlessness, the SGRQ and the Disability Index of the Health Assessment Questionnaire (HAQ DI), and underwent evaluation with complete pulmonary function testing (PFT), 6-minute walk distance (6MWD) and high-resolution computed tomography (HRCT).
Results. The SGRQ ‘activity’ scores inversely correlated with the 6MWD (r = –0.86, P < 0.001) and forced vital capacity percentage of predicted values (r = –0.47) and directly correlated with HRCT (r = 0.41, P < 0.05), MRC (
= 0.64, P < 0.001) or HAQ DI scores (r = 0.62, P < 0.001), independently of disease duration or subset. On the contrary, HAQ DI scores were influenced by those variables and corrected correlations with 6MWD (r = 0.56, P < 0.001) or HRCT scores (r = 0.36, P = NS) were less strong than those observed with the SGRQ.
Conclusions. The SGRQ, although not specifically designed for scleroderma, is a valid respiratory-specific questionnaire for the evaluation of HRQoL in patients with SSc-related ILD. The SGRQ performs better in relation to exercise capacity and lung imaging than other non-respiratory-specific questionnaires widely used in scleroderma studies. Further studies are needed to address its ability to assess changes over time or in response to therapy.
KEY WORDS: Systemic sclerosis, Quality of life, Interstitial lung disease
Submitted 22 March 2006;
revised version accepted 19 May 2006.
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