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Rheumatology Advance Access originally published online on May 11, 2007
Rheumatology 2007 46(7):1052-1056; doi:10.1093/rheumatology/kem112
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

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Fifty years of anti-ds DNA antibodies: are we approaching journey's end?

D. A. Isenberg, J. J. Manson, M. R. Ehrenstein and A. Rahman

Centre for Rheumatology Research, Division of Medicine, University College London, London W1T 4JF, UK.

Correspondence to: David Isenberg, MD, FRCP, Centre for Rheumatology Research, Division of Medicine, University College London, Room 331, 3rd Floor, 46 Cleveland Street, London W1T 4JF, UK. E-mail: d.isenberg{at}ucl.ac.uk


  Abstract

The year 2007 marks the 50th anniversary of the identification of antibodies to double-stranded (ds) DNA. Whilst widely regarded as synonymous with patients who have systemic lupus erythematosus (SLE), doubts have been raised about their significance and the extent to which they are genuinely part of the pathogenesis of the disease rather than being mere bystanders. Problems with assays used to detect them are still evident but they remain widely utilized both to help establish the diagnosis of SLE and to monitor the progress of the disease. This review explores each of these aspects and concludes that whilst some way short of ideal, their measurement remains a useful criterion for the disease and some of these antibodies do appear to be genuinely pathogenic. However, further research is needed to establish beyond ‘reasonable doubt’ whether they are merely part of the spectrum of anti-nucleosome antibodies, the precise mechanisms by which they ‘exert’ their pathogenic effects and to what extent blocking them would be a useful therapeutic goal.

KEY WORDS: DNA antibodies, SLE, Lupus nephritis

Submitted 5 January 2007; revised version accepted 13 March 2007.
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