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Rheumatology Advance Access originally published online on October 4, 2008
Rheumatology 2008 47(12):1768-1770; doi:10.1093/rheumatology/ken374
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis

P. Harrison1, J. J. Pointon1, K. Chapman1, A. Roddam2 and B. P. Wordsworth1

1Institute of Musculoskeletal Sciences and 2Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK.

Correspondence to: P. Harrison, Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK. E-mail: pille.harrison{at}ndos.ox.ac.uk


  Abstract

Objectives. IL-1 has a central role mediating inflammation and joint destruction in RA. Single nucleotide polymorphisms (SNPs) and haplotype structure in the promoter region can modulate IL-1 function. This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies.

Methods. Using PCR-based methods, 756 RA patients and 625 healthy controls (HCs) were genotyped for IL-1A (–889 C/A, rs17561), IL-1B (–511 A/G, rs16944), IL-1B (–1464 C/G, rs1143623) and IL-1B (–3737 G/A, rs4848306) SNPs. Further meta-analysis was performed for IL-1B (–511 A/G) incorporating 3712 RA patients and 2331 HC from six association studies.

Results. The IL-1B (–1464 C/G) G allele was found to be less common in the RA group [P = 0.01; odds ratio (OR) 1.24; 95% CI 1.04, 1.48]. There was no association between IL-1 SNPs and the presence of HLA-DRB1 shared epitope, RF or clinical characteristics. Meta-analysis revealed statistically significant association between IL-1B (–511 A/G) and RA (P = 0.02; pooled OR 1.13; 95% CI 1.02, 1.26).

Conclusions. There may be a protective effect in RA from the IL-1B (–1464 C/G) G variant. No direct association between the polymorphisms studied and clinical severity characteristics were observed. Further meta-analysis revealed IL-1B (–511 A/G) to be associated with increased susceptibility to RA.

KEY WORDS: Rheumatoid arthritis, Meta-analysis, Interleukin-1, Interleukin-1A, Interleukin-1B, Association study, Major histocompatibility complex, Radiographic severity, Genetics, Polymorphism

Submitted 1 July 2008; revised version accepted 18 August 2008.
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