Skip Navigation


Rheumatology Advance Access originally published online on January 31, 2008
Rheumatology 2008 47(6):771-776; doi:10.1093/rheumatology/kem352
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
47/6/771    most recent
kem352v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Paunovic, V.
Right arrow Articles by Gadina, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paunovic, V.
Right arrow Articles by Gadina, M.
Related Collections
Right arrow Rheumatoid Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REVIEWS

Signalling, inflammation and arthritis

Crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity

V. Paunovic, H. P. Carroll, K. Vandenbroeck and M. Gadina

Centre for Cancer Research and Cell Biology. Queen's University Belfast, UK.

Correspondence to: M. Gadina, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland, UK. E-mail: m.g.gadina{at}qub.ac.uk


  Abstract

Autoimmune diseases such as rheumatoid arthritis are the consequence of a persistent imbalance between pro- and anti-inflammatory immune mechanisms leading to chronic inflammation. The action of several cytokines is at the basis of this complex process. This review is focused on the signalling events triggered by two major groups of cytokines, namely the IL-12 and IL-17 families, which in the past few years have been shown to have a prominent role in the pathogenesis of such diseases. In particular, we will focus on the signalling cascades set in motion by such cytokines and how this may relate to the pathogenesis of human immune and inflammatory disorders as knowledge of such cascades may help in the development of novel therapeutic approaches for such diseases.

KEY WORDS: Inflammation, Autoimmunity, Rheumatoid arthritis, Cytokines, Interleukins, Interferons, T helper, Signal transduction, Jak–STAT pathway, Animal models

Submitted 18 May 2007; revised version accepted 30 November 2007.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.