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Rheumatology 2008 47(Supplement 3):iii9-iii12; doi:10.1093/rheumatology/ken151
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Challenges of lupus pregnancies

A. Doria1, A. Tincani2 and M. Lockshin3

1Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Padova, 2Rheumatology and Clinical Immunology, Spedali Civili, University of Brescia, Italy and 3Joan and Sanford Weill College of Medicine of Cornell University, Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, New York, USA.

Correspondence to: A. Doria, Division of Rheumatology, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy. E-mail: adoria{at}unipd.it


  Abstract

SLE primarily affects young females of childbearing age and fertility is generally conserved. SLE is a predominantly Th2-mediated disease and a progressive Th1/Th2 cytokine shift is seen in the fetal–maternal unit as well as in maternal circulation. Whether this fact affects pregnancy is unknown. Pregnancy represents a challenge for lupus patients and their physicians. However, the majority of SLE patients can now have successful pregnancies and deliver healthy babies, a result of our knowledge of the risks that SLE patients have to face during pregnancy, the preventive and therapeutic measures that we adopt, when necessary, and the close and appropriate rheumatological, obstetric and neonatal monitoring. All of these aspects are discussed in this review.

KEY WORDS: Pregnancy, Pregnancy outcomes, Systemic lupus erythematosus, Th1 and Th2 cytokines, Systemic lupus erythematosus activity, Congenital heart block

Submitted 4 March 2008; Accepted 27 March 2008


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Rheumatology, June 1, 2008; 47(suppl_3): iii1 - iii1.
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