Skip Navigation

Rheumatology 2008 47(Supplement 5):v27-v28; doi:10.1093/rheumatology/ken274
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Frommer, K. W.
Right arrow Articles by Müller-Ladner, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frommer, K. W.
Right arrow Articles by Müller-Ladner, U.
Related Collections
Right arrow Systemic Sclerosis
Right arrow Experimental Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Rheumatology issue: Update in systemic sclerosis [View the issue table of contents]

Expression and function of ETA and ETB receptors in SSc

K. W. Frommer1 and U. Müller-Ladner1

1Department of Internal Medicine and Rheumatology, Justus-Liebig University Gießen, Kerckhoff-Klinik Bad Nauheim, Bad Nauheim, Germany.

Correspondence to: K. W. Frommer, Justus-Liebig-Universität Gießen, Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik GmbH, Abt. Rheumatologie und Klin. Immunologie, Franz-Groedel-Institut, Benekestr. 2-8, D-61231 Bad Nauheim, Germany. E-mail: k.frommer{at}kerckhoff-klinik.de


  Abstract

Endothelin (ET) receptors are widely expressed within the human body with one of their major functions being regulation of the vascular tone. Pulmonary arterial hypertension and other complications associated with SSc are related to the function and or dysregulation of these receptors. As ET receptors also play a crucial role in SSc, this review will discuss the expression and physiological functions of ET receptors in the human organism, their signalling pathways, the complications of diseases they are associated with and their importance as a therapeutic target in SSc.

KEY WORDS: Expression, Function, EndothelinA receptors, EndothelinB receptors, Endothelin, Systemic sclerosis, Scleroderma, Diseases, Signalling

Submitted 1 May 2008; Accepted 18 June 2008


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.