Rheumatology Advance Access originally published online on February 4, 2009
Rheumatology 2009 48(4):390-394; doi:10.1093/rheumatology/ken504
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Evaluation of the clinimetric properties of the Early Inflammatory Arthritis—self-administered comorbidity questionnaire
1Division of Rheumatology, Sir Mortimer B. Davis – Jewish General Hospital, 2Division of Rheumatology, 3Department of Mathematics, McGill University and 4Service de Rhumatologie, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Correspondence to: Murray Baron, Division of Rheumatology, Sir Mortimer B. Davis – Jewish General Hospital, Suite A-216, 3755 Cote Sainte Catherine Rd, Montreal, Quebec, Canada H3T 1E2. E-mail: mbaron{at}rhu.jgh.mcgill.ca
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Objectives. To adapt the self-administered comorbidity questionnaire (SCQ) into the Early Inflammatory Arthritis—SCQ (EIA-SCQ) and assess its clinimetric properties in EIA.
Methods. The EIA-SCQ and indices of disease activity, function, pain, health-related quality of life (HRQoL) and health resource utilization were administered to 320 patients with EIA. Twenty patients completed the EIA-SCQ a second time 1 week later. Construct validity was evaluated by testing the hypotheses that a valid comorbidity index would correlate well with age, weakly with HRQoL and recent resource utilization and poorly with indices of disease activity, function and pain.
Results. The intra-class correlation coefficient between repeat scores was 0.93 (95% CI 0.83–0.97). Kappa values for individual items ranged from 0.64 to 1.0. EIA-SCQ scores correlated moderately with age (Tau B = 0.29, P < 0.001) and weakly with function (HAQ-DI Tau B = 0.09, P = 0.03), pain (McGill Pain Questionnaire Tau B = 0.09, P = 0.05), some measures of HRQoL [the SF-36 mental component score (MCS) Tau B = – 0.08, P < 0.05; World Health Organization Disease Assessment Schedule II score Tau B = 0.09, P = 0.03] and a measure of resource utilization (number of tests in the last 4 months Tau B = 0.10, P = 0.04). The EIA-SCQ did not correlate with other measures of disease activity, another HRQoL measure [SF-36 physical component score (PCS)] or other measures of resource utilization.
Conclusions. The EIA-SCQ is reliable and valid for use in EIA. It has the potential to become a useful measure of comorbidity in outcome studies of EIA when the resources for a full medical chart review are unavailable.
KEY WORDS: RA, Arthritis, Comorbidity, Psychometrics, Questionnaires, Early inflammation
Submitted 8 April 2008;
revised version accepted 15 December 2008.
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