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Rheumatology Advance Access originally published online on July 14, 2009
Rheumatology 2009 48(9):1133-1136; doi:10.1093/rheumatology/kep177
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The influence of diffuse idiopathic skeletal hyperostosis on bone mineral density measurements of the spine

L. Anneloes Westerveld1, Jorrit-Jan Verlaan1, Marnix G. E. H. Lam2, Wendy P. Scholten2, Ronald L. A. W. Bleys3, Wouter J. A. Dhert1,4 and F. Cumhur Oner1

1Department of Orthopaedics, 2Department of Radiology and Nuclear Medicine, 3Department of Anatomy, University Medical Center Utrecht and 4Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.

Correspondence to: Jorrit-Jan Verlaan, Department of Orthopaedics, University Medical Center Utrecht, G 05.228, PO Box 85500, 3508 GA Utrecht, The Netherlands. E-mail: j.j.verlaan{at}umcutrecht.nl


  Abstract

Objectives. BMD has been described to be increased in patients with DISH. The contribution of the ossified anterior longitudinal ligament (ALL) on vertebral body BMD is currently unknown. We investigated the influence of DISH on BMD measurements using an experimental DXA scanning protocol.

Methods. Ten DISH specimens and 10 matched human cadaveric spines were used. After assessment of the localization and orientation of the ossified ALL with CT, BMD was measured using an experimental DXA protocol, exploiting the asymmetry of DISH in the thoracic spine. For controls, identical orientations were used and both groups were compared for differences in BMD.

Results. Specimens with DISH displayed a significantly higher BMD than their matched controls when the ossified ALL was present in the scanning field. Measurements of the left half of the spine were comparable for DISH specimens and controls (P = 0.446). The right–left difference in anteroposterior view was statistically significant within DISH specimens (P = 0.001), but not in controls (P = 0.825).

Conclusions. The variability in measurements in different scanning orientations suggests a substantial contribution of the ossified ALL to the total BMD in DISH specimens, ranging from 23.6 to 39.0%. Vertebral body BMD does not seem to be increased, as demonstrated by comparable BMDs in the unaffected left half of the spine. It is suggested that routine anteroposterior DXA scanning may overestimate the true vertebral body BMD in DISH patients.

KEY WORDS: Diffuse idiopathic skeletal hyperostosis, Bone mineral density, Dual energy X-ray absorptiometry, Ossification, Spine

Submitted 1 April 2009; revised version accepted 27 May 2009.
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