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© 1973 British Society for Rheumatology

The Response of Human Tissue In Vitro for Assaying Anti-Inflammatory Action

Lucille Bitensky and J. Chayen


  Abstract

THE biochemical activity of individual cells in a complex tissue can be determined by quantitative cytochemical methods where the activities are measured by microdensitometry of the optically selected cells in a tissue section. By such means it has been confirmed that the lysosomes of the cells lining the synovium of human rheumatoid joints are abnormally labile. It has also been shown that human synovial tissue can be maintained in vitro so that it remains identical, structurally and biochemically, with the tissues at biopsy. The effect of glucocorticoids on improving lysosomal stability in synovial lining cells in vitro, is similar to that measured in biopsies of treated patients. Thus the in vitro treatment is a good indication of what pertains in vito. Benorylate, applied in vitro to human rheumatoid synovia, has stabilised the lysosomes of the synovial lining cells at least to the same degree as that obtained with relatively high concentrations of prednisolone or hydrocortisone.


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