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© 1983 All rights reserved

Enteric Bacteria and HLA-B27 Associated Cell Surface Modification in Patients with Seronegative Spondarthritis

J. Edmonds, A. F. Geczy, J. S. Sullivan, J. K. Prendergast, L. I. Upfold and H. V. Bashir


  Abstract

Cytotoxic studies indicate cross-reactivity between some enteric organisms and cells obtained from the majority of patients with ankylosmg spondylitis. Preliminary studies suggest that the factor responsible for cross-reactivity may be generated by a bacterial plasmid. However, the mechanism mediating the interaction between the HLA-B27 positive cell and the bacterial antigen is at present unknown.

KEY WORDS: Ankylosmg spondylitis, Klebsiella, HLA-B27, Enteric bacteria, Seronegative arthritis


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