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© 1985 All rights reserved

Interleukin-1: Its Relevance to Rheumatoid Arthritis

M.E.J. Billingham


  Abstract

For many years investigators have sought a ‘key’ mediator of rheumatoid arthritis (RA)-an agent whose activities might explain the well-characterized chronic, destructive pathology of RA. Intcrlcukin-1 (IL-1) has been demonstrated to induce dcgradativc enzyme release from mesenchyma! cells that are present at sites of bony erosion The IL-1 released locally during the erosive process may also be responsible for increased hepatic production of acute phase proteins-levels of which have been correlated with progressive radiographic changes in RA

If IL-1 docs mediate the pathogencsis of RA. the challenge to the pharmaceutical industry will be to provide agents thai inhibit those IL-1 effects involved in disease progression while allowing the many potentially beneficial actions of IL-1 to continue at a functional level.

KEY WORDS: Interleukin-1, Rheumatoid arthritis, Bone crosion


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