Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dinarello, C.A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dinarello, C.A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1985 All rights reserved

Interleukin-1: Prospects for Biology

C.A. Dinarello


  Abstract

Polypcplidcs from activated monoevtes and macrophages have altractcd considerable interest as mediators of host responses to infection, injury and various immunological reactions One of these polypcptides(ora family of closely related peptidcs) is intcrlcukin-1 (IL-1) IL-1 has been studied for decades for usability to induce many components of the acute phase response, notably fever, synthesis of acute phase reactants and the redistribution of ammo acids, iron and zinc Currently, many biological activities have been attributed to IL-1 cDNA to human and mouse IL-1 have been cloned and the availability of large quantities of homogeneous rccombinant IL-1 will unquestionably result in the resolution of problems associated with insufficient amounts of purified IL-1 In addition, there will be new directions for IL-1 research and its relationship to clinical disease. In this report, recent developments at the molecular level of IL-1 will be discussed with particular emphasis on implications for future research trends in the biology of IL-1 These include confirmation of the multiple biological activities of IL-1 using rccombinant IL-1. development of sensitive immunoassays for detecting IL-1 in human body fluids, the discovery of other IL-1 genes identification of specific IL-1 sequences which arc required for certain biological effects and testing of potential IL-1 antagonists

KEY WORDS: Interleukin-1, biological effects, Molecular biology


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.