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© 1985 All rights reserved

Mononuclear Cell Factor and Synovial Factor are Closely Related to, or Identical with, Interleukin-1

P.R. Elford, H.J. Richardson, R.M. Sharrard, J.E. Meats, H. Skjodt, R. A. D. Bunning, A. Crawford and R. G. G. Russell


  Abstract

We have studied the biological activities of intercellular mediators derived from monocytcs (mononuclcarccll factor. MCF) and from synovium (synovial factor. SF). These factors may be related to catabolin, a protein that induces cartilage resorption in vitro In addition, there is now evidence to suggest that MCF may be related to the monokinc intcrleukin-1 (IL-1) In order to clarify the relationship between these factors we have partially purified MCF and SF and examined their biological activity using standard assays for IL-1. catabolin and MCF/SF We find that all connective tissue-stimulating activities copunfy with IL-1 and possess biochemical characteristics that arc indistinguishable from IL-1. The study indicates that both human monocytcs and synovium produce factors (originally termed MCF and SF) that are closely related to. or identical with, IL-1 and suggests that this protein may participate in cellular interactions that occur within the rheumatoid joint.

KEY WORDS: Cartilage, Chondrocytes, Interleukin-1, Rheumatoid arthntis


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