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© 1988 All rights reserved

Molecular Biology of the HLA-B27 Locus

Elisabeth H. Weiss, Kathi Bloemer, Christa Doerner, W. Kuon, Margot Lang, Heike Pohla, M. Schattenkirchner and G. Riethmüller

Correspondence to Dr. Weiss


  Abstract

The molecular biology of the HLA-B27 locus is reviewed. The HLA-B27 gene itself does not differ between healthy individuals and ankylosing spondylitis patients. Several unique features of the HLA-B27 molecule have been identified and one epitope was proposed to cross-react with bacterial proteins

KEY WORDS: DNA, Intron probe, Polymorphisms, Cosmid clones


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