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© 1988 All rights reserved

Experimental Yersinia-Associated Arthritis in the Spontaneously Hypertensive Rat

P. Toivanen, R. Merilahti-Palo, C. Gripenberg, K. -O. Söderström and U. -M. Jaakkola

Correspondence to Dr Toivanen


   Abstract

Stertle arthritis resembling human reactive arthritis was mduced in spontaneously hypertensive SHR rats by mtravenous mjection of live Yersinia enterocolitica 0:8. Histologically the synovitis appears as proliferation of the lining cell layer, with inflammatory cells present in the subsynovium The inflammatory cells are mostly lymphocytes Infection with Yersinia enterocolitica 0.3 or Yersinia Pseudotuberculosis did not induce arthritis Susceptibthty to Yersinia-associated arthritis is not determined by the major histocompatibility complex (MHC), since rats of the normotensive control strain (WKY) with the same MHC do not develop arthritis

KEY WORDS: Yersinia, Arthritis, Reactive arthritis, Synovium


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