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© 1988 All rights reserved

Rabbit Antisera to Enterobacteriaceae Isolated from HLA-B27 Positive Patients with Ankylosing Spondylitis (AS) are Lytic for the Mononuclear Cells of as Patients

C. J. Beukelman, A. van Leeuwen, P. C. Aerts, E. van Kregten, S. van Bree, J. J. van Rood, J. M. N. Willers and H. van Dijk

Correspondence to Dr. van DIJK


  Abstract

Vaccines prepared from Gram-negative bacteria isolated from the stools of HLA-B27 positive AS patients were used to immunize rabbits. Three of the sera obtained were lytic in vitro for the mononuclear cells of HLA-B27 positive AS patients. One of these sera discriminated between AS patients and healthy HLA-B27 positive individuals Cytolysis was determined in an automated, non-radioactive assay based on the release of carboxy-fluorescein diacetate and the incorporation of propidium iodide

KEY WORDS: Ankylosing spondylitis, Cytotoxicity, Gram-negative bacteria, HLA-B27


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