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© 1988 All rights reserved

Expression of HLA Antigens on the Human Uvea

D. Abi-Hanna and D. Wakefield

Corresponding author: Prof. Dennis Wakefield


  Abstract

We examined the expression of HLA antigens on post-mortem human uveal tissues and on cultured uveal cells. There was no in vivo expression of class I or class II antigens in these tissues, except for the blood vessel endothelium which expressed class I but not class II antigens. Tissue cultured uveal cells were found to express class I antigens. The effect of interferon-{alpha} and interferon-β on the in vitro expression of the antigens was examined Class I HLA antigen expression was enhanced by both interferon-{alpha} and interferon-β, while class II HLA antigens were induced on up to 100% of cultured cells, but only by interferon-β. These findings are discussed in their relation to immune mechanisms occuring in ocular inflammatory disorders.

KEY WORDS: Ocular tissue, Interferon, Tissue type


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