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© 1988 All rights reserved

Klebsiella Antibodies in Ankylosing Spondylitis and Proteus Antibodies in Rheumatoid Arthritis

A. Ebringer, N. L. Cox*, I. Abuljadayel, M. Ghuloom, S. Khalafpour, T. Ptaszynska, F. Shodjai-Moradi and C. Wilson

Correspondence: Dr. Alan Ebringer, Department of Rheumatology, Middlesex Hospital, London W1. England.


  Abstract

Antibodies io Klebsiella. but not to other bacteria, have been shown to be present in patients with active ankylosing spondylitis (AS) by seven different techniques.

Antibodies to Proteus, but not to E. coli or Klebsiella. have been shown to be present in patients with active rheumatoid arthritis (RA) by three different techniques.

It is suggested AS and RA are forms of reactive arthritis, to Klebsiella and Proteus respectively, probably mediated by cross-reactivity to HLA antigens

KEY WORDS: Ankylosing spondylitis, Rheumatoid arthritis, Klebsiella, Proteus, HLA-DR4

* Department of Rheumatology, Royal Hampshire Hospital, Winchester, England


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