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© 1988 All rights reserved

Antibodies to Klebsiella and Proteus Microorganisms in Ankylosing Spondylitis and Rheumatoid Arthritis Patients Measured by ELISA

S. Khalafpour, A. Ebringer, I. Abuljadayel and M. Corbett

Correspondence Dr. Alan Ebringer. Department of Rheumatology. The Middlesex Hospital, London WI UK


  Abstract

Antibodies to Klebsiella oxytoca and Proteus nurabilis in 21 active ankylosing spondylitis (AS). 13 active rheumatoid arthritis (RA), 19 inactive RA patients and 18 healthy controls were measured using enzyme-linked immunosorbent assay (ELISA)

Elevated anti-Klebsiella antibodies were demonstrated in active AS patients compared to active RA (p< (I (II). inactive RA patients (p< 0.001) and controls (p< 0 DOS) When measuring antibodies to Protein, active RA patients showed higher levels of antibodies compared to active AS patients (p< 0.005) and healthy controls (p< 0.05)

Further investigations are required to assess the role of Klebsiella and Proteus microorganisms in AS and RA respectively

KEY WORDS: Ankylosing spondylitis, Rheumatoid arthritis, Klebsiella, Proetus


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