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© 1989 British Society for Rheumatology

Oral Contraceptives and the Risk of Rheumatoid Arthritis: A Meta-Analysis of a Conflicting Literature

Isabelle Romieu, M. Hernandez-Avila and M. H. Liang

Department of Epidemiology, Harvard School of Public Health, Boston, MA; Directorate of Epidemiology, Mexico City, Mexico and Departments of Medicine and Rheumatology/ Immunology, Harvard Medical School, Brigham and Women's Hospital, Robert B. Brigham Multipurpose Arthritis Center Boston, MA 02115, USA

Correspondence to Dr. Liang, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA


  Abstract

Since an original report suggesting a protective effect of oral contraceptives on rheumatoid arthritis incidence, 12 studies from four countries have shown conflicting results. Using the method of DerSimonian and Laird [1] all available studies (including two completed but not as yet published) were evaluated. Overall, the relative risk of oral contraceptive use on the development of RA were less than unity. When summary statistics for case-control studies were examined, a small protective effect was noted, but was not statistically significant.


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