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© 1989 British Society for Rheumatology

Oral Contraceptive Treatment for Rheumatoid Arthritis: An Open Study in 10 Female Patients

J. M. W. Hazes*, B. A. C. Dijkmans*, J. P. Vandenbroucke{dagger} and A. Cats*

* Departments of Rheumatology
{dagger} Departments of Clinical Epidemiology, University Hospital Leiden, The Netherlands

Correspondence to Dr. Hazes, Department of Rheumatology, Building 1, C2-Q, University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands


  Abstract

Ten female patients (median age 37 years, range 23-45) with active rheumatoid arthritis (RA) (nine seropositive, one seronegative, seven erosive, three non-erosive) were treated during 6 months with one of the earlier, i.e. higher dosed, oral contraceptives (Lyndiol®, each tablet containing 2.5 mg lynestrenol and 0.05 mg ethinyloestradiol). None of the patients had been previously treated with a disease modifying drug. In one patient therapy with Lyndiol® was stopped within 14 days after the start because of vomiting. Three out of the remaining nine patients stopped the therapy after 3 months because of inefficacy. Erythrocyte sedimentation rate (ESR) deteriorated during the study. Except for the number of swollen joints no clinical or laboratory parameters improved.

We conclude that Lyndiol® has no disease modifying effect in rheumatoid arthritis.


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