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© 1995 British Society for Rheumatology

Sulphasalazine, Sulphapyridine or 5-Aminosalicylic Acid—which is the Active Moiety in Rheumatoid Arthritis?

H. A. Bird

Clinical Pharmacology Unit, Chapel Allerton Hospital Chapeltown Road, Leeds LS7 4SA


  Abstract

Sulphasalazine is cleaved into 5-aminosalicylic acid and sulphapyridine by colonic bacteria. The bulk of evidence favours sulphapyridine rather than 5-aminosalicylic acid as the active moiety (as well as the main producer of side-effects) though a therapeutic action from the 30% of sulphasalazine that is absorbed unaltered also cannot be excluded.

KEY WORDS: Sulphasalazine, sulphapyridine, 5-ASA


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