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© 1995 British Society for Rheumatology

Overview of Combination Second-Line or Disease-Modifying Antirheumatic Drug Therapy in Rheumatoid Arthritis

H. J. Williams

Division of Rheumatology, University of Utah School of Medicine Salt Lake City, Utah, USA

vCorrespondense to: H. Williams, 50 North Medical Drive, Salt Lake City, UT 84132, USA.


  Abstract

This article discusses the use of combinations of disease-modifying antirheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA). Patients with RA have a disease that can be disabling and life threatening and current therapies do not prevent these complications. The need for more aggressive therapy is apparent The rationale for combinations of DMARDs is explored and the efficacy and safety of reported combinations is summarized. The variables to be reviewed in selecting a combination of DMARDs are examined. Newer approaches employing multiple DMARDs will be considered.

KEY WORDS: Disease-modifying antirheumatic drugs, Combination, Treatment, Rheumatoid arthritis


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