Skip Navigation



Rheumatology Advance Access published online on July 14, 2008
Rheumatology, doi:10.1093/rheumatology/ken255
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
47/9/1400    most recent
ken255v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yong, P. F. K.
Right arrow Articles by Khamashta, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yong, P. F. K.
Right arrow Articles by Khamashta, M. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Management of hypogammaglobulinaemia occurring in patients with systemic lupus erythematosus

P. F. K. Yong1,2, L. Aslam2, M. Y. Karim2,3 and M. A. Khamashta2

1Department of Clinical Immunology, Kings College Hospital, 2Louise Coote Lupus Unit, St Thomas’ Hospital, London and 3Department of Immunology, Frimley Park Hospital, Frimley, UK.

Correspondence to: M. Y. Karim, Louise Coote Lupus Unit, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, UK. E-mail: yousuf.karim{at}gstt.nhs.uk


  Abstract

Objectives. Systemic lupus erythematosus (SLE) is typically associated with hypergammaglobulinaemia but has been described in the setting of hypogammaglobulinaemia as well. The purpose of this article is to describe various cases of SLE and hypogammaglobulinaemia, review the literature and present management strategies for hypogammaglobulinaemia in SLE.

Methods. We describe five patients with SLE and antibody deficiency, and review the literature exploring the relationship between the two.

Results. Various types of antibody deficiency syndromes, including common variable immunodeficiency (CVID), IgA deficiency, IgM deficiency, drug-induced hypogammaglobulinaemia and hypogammaglobulinaemia secondary to nephrotic syndrome can occur in SLE. Antibody deficiency states can be treated with antibiotics and replacement immunoglobulin therapy (particularly CVID) but sometimes close monitoring is all that is required.

Conclusion. Measurement of immunoglobulin levels is useful in SLE to identify coexisting antibody deficiency and the later development of hypogammaglobulinaemia. This allows monitoring and appropriate treatment to be instituted.

KEY WORDS: Systemic lupus erythematosus, Primary antibody deficiency, Immunodeficiency, Hypogammaglobulinaemia, Immunoglobulin G

Submitted 21 September 2007; revised version accepted 13 June 2008.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.