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Rheumatology 1999; 38: 1020-1021
© 1999 British Society for Rheumatology

Letters to the Editor

Surfactant treatment for osteoarthritis

P. Vecchio1, R. Thomas2 and B. A. Hills2,3

1 Rheumatology Department, Princess Alexandra Hospital,
2 Department of Medicine, University of Queensland, and
3 Paediatric Respiratory Research Centre, Mater Children's Hospital, Brisbane, Australia

Correspondence to: B. A. Hills, Paediatric Respiratory Research Centre, Mater Children's Hospital, South Brisbane, Queensland 4101, Australia.

SIR, Much scientific and clinical data have been collected [1, 2] to support the theory [3, 4] that the vital load-bearing boundary lubricant in the joint is surface-active phospholipid (SAPL). Oligolamellar layers of SAPL adsorbed to the articular surface have been observed by electron microscopy [4] to be the outermost hydrophobic layer which imparts superb lubrication, reducing wear and lowering friction to physiological levels that are extremely low by engineering criteria. SAPL is also an effective release agent capable of inhibiting . . . [Full Text of this Article]

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