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Rheumatology 1999; 38: 737-738
© 1999 British Society for Rheumatology

Paediatric Rheumatology: Autologous Stem Cell Transplantation in Rheumatic Diseases of Childhood

Autologous stem cell transplantation: an alternative for refractory juvenile chronic arthritis

Series Editor: P. Woo

W. Kuis, N. M. Wulffraat and R. E. Petty1

Department of Paediatric Immunology, University Hospital for Children `Het WKZ', Utrecht, The Netherlands and
1 Department of Paediatrics, British Columbia Children's Hospital, Vancouver, Canada

Correspondence to: N. M. Wulffraat, Department of Paediatric Immunology, University Hospital for Children, `HET Wilhelmina Kinderziekenhuis', Utrecht, The Netherlands.

Juvenile chronic arthritis (JCA), the most frequent autoimmune disease of childhood, is not a benign disease. Functional disability occurs in 20–30% of patients with JCA and 5–10% develop a serious handicap [1]. Children with a polyarticular and systemic-onset form are especially at risk. To improve the outcome of these patients is a challenge for paediatric rheumatologists.

To improve disease outcome, immunosuppressive drugs like methotrexate [2], cyclosporin [3] . . . [Full Text of this Article]

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