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Rheumatology 1999; 38: 762-763
© 1999 British Society for Rheumatology

Paediatric Rheumatology: Autologous Stem Cell Transplantation in Rheumatic Diseases of Childhood

Rationale for high-dose cyclophosphamide and medium-dose total body irradiation in the conditioning of children with progressive systemic and polyarticular juvenile chronic arthritis before autologous stem cell transplantation

Series Editor: P. Woo

J. M. Vossen, D. M. C. Brinkman, B. Bakker, P. M. Hoogerbrugge and R. ten Cate

Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands

Despite the fact that the aetiology of juvenile chronic arthritis (JCA) is unknown, there is ample indirect evidence of a pivotal role of T cells in the onset and probably also in the maintenance of this autoimmune disease. Notwithstanding adequate first- and second-line anti-rheumatic therapy, systemic-onset JCA and polyarticular JCA will lead to destructive arthritis, growth retardation and severe invalidity in 10–25% of the . . . [Full Text of this Article]

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