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Rheumatology 1999; 38: 801-804
© 1999 British Society for Rheumatology

Editorials

Metabolic bone disease in patients with inflammatory bowel disease

I. Bjarnason

Department of Medicine, Guy's, King's, St Thomas' Medical School, Bessemer Road, London SE5 9PJ, UK

Patients with inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) are no more immune to the development of osteoporosis than the general population [1]. Initial estimates suggested that ~30% of patients with severe Crohn's disease and somewhat fewer patients with ulcerative colitis had metabolic bone disease, either osteoporosis or osteomalacia [1–3]. The pathogenesis was thought to relate to ileal and small intestinal involvement of disease, or surgical resections, causing vitamin D and/or calcium malabsorption, oestrogen deficiency, malnutrition or treatment with cholestyramine in Crohn's disease [1, 2, 4–7] and corticosteroids in ulcerative colitis.

With the introduction of dual X-ray absorptiometry (DXA) to quantitate bone mineral density (BMD) reliably, reproducibly and with ease, and its application to patients with IBD, the above prevalence rates and mechanisms of reduced BMD have been reviewed. Pigot et al. [8] . . . [Full Text of this Article]

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S. S. Yeap and D. J. Hosking
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[Abstract] [Full Text] [PDF]