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Rheumatology 2000; 39: 105-106
© 2000 British Society for Rheumatology

Letters to the Editor

Topical tacrolimus for recalcitrant leg ulcer in rheumatoid arthritis

H.-C. Schuppe, D. Richter-Hintz, H. E. Stierle1, B. Homey, T. Ruzicka and P. Lehmann

Department of Dermatology, Heinrich Heine University, Moorenstraße 5, D-40225 Duesseldorf and
1 Department of Rheumatology, Sankt Josef Hospital, Bergstraße 6–12, D-42105 Wuppertal, Germany

SIR, Chronic leg ulcers have been reported to occur in up to 10% of patients with rheumatoid arthritis (RA) at some stage of their disease [1]. Most patients reveal seropositive erosive disease with significant functional impairment and high levels of rheumatoid factor [2]. With regard to aetiological factors, venous insufficiency, trauma or pressure, and peripheral arterial disease appear to be common causes [2, 3]. However, other disorders such as cutaneous vasculitis, pyoderma gangrenosum or Felty's syndrome need to be considered [2–4]. . . . [Full Text of this Article]

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