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Rheumatology 2000; 39: 106-108
© 2000 British Society for Rheumatology

Letters to the Editor

Successful treatment of hepatitis B-associated polyarteritis nodosa with a combination of lamivudine and conventional immunosuppressive therapy: a case report

D. Maclachlan, M. Battegay1, A. L. Jacob2 and A. Tyndall

University Department of Rheumatology, Felix Platter Spital, Burgfelder Strasse 101, Basel,
1 University Medical Outpatient Department and
2 University Institute of Diagnostic Radiology, Kantonsspital Basel, Petersgraben 4, Basel, Switzerland

Correspondence to: D. Maclachlan, University Department of Rheumatology, Felix Platter Spital, Burgfelder Strasse 101, CH-4055 Basel, Switzerland.

SIR, Treatment of hepatitis B virus (HBV)-associated polyarteritis nodosa with immunosuppression is problematic due to possible enhancement of viral replication [1], which may also possibly worsen the vasculitis by enhancing viral antigenaemia.

Lamivudine has recently been shown to suppress the replication of HBV by >98% [2–5] and could thus allow the use of conventional immunosuppressive agents to control the vasculitis. We report the case of a patient treated successfully in this manner.

The patient, a general surgeon, developed diffuse myalgias . . . [Full Text of this Article]

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A. Filer, A. Hughes, K. Kane, D. Mutimer, P. Jobanputra, D. Maclachlan, M. Battegay, A. L. Jacob, and A. Tyndall
Successful treatment of hepatitis B-associated vasculitis using lamivudine as the sole therapeutic agent
Rheumatology, September 1, 2001; 40(9): 1064 - 1065.
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