Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Filaci, G.
Right arrow Articles by Indiveri, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Filaci, G.
Right arrow Articles by Indiveri, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2000; 39: 1289-1290
© 2000 British Society for Rheumatology

Letters to the Editor

Autoantibodies to neutrophilic proteases in a case of panniculitis by deficit of {alpha}1-antitrypsin

G. Filaci, P. Contini, P. Barbera, L. Bernardini and F. Indiveri

Department of Internal Medicine, University of Genoa, Italy

The first 10% of the full text of this article appears below.

SIR, {alpha}1-Antitrypsin is a serine protease inhibitor whose principal targets are neutrophil elastase, proteinase 3 and cathepsin G [1]. Several mutants of the gene encoding {alpha}1-antitrypsin have been identified; the non-functional Z variant is found in 1–2% of Caucasians of European descent [2]. ZZ homozygotes develop a disease leading to lung emphysema and/or liver cirrhosis [3]. Panniculitis is a rare manifestation of the disease [4]. The pathogenesis probably relates to the lack of inhibition of neutrophil proteases due to {alpha}1-antitrypsin . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?