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Rheumatology 2000; 39: 1312-1315
© 2000 British Society for Rheumatology

Editorials

Novel insights into the pathogenesis of osteoporosis: the role of intrauterine programming

C. Cooper, K. Walker-Bone, N. Arden and E. Dennison

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK

The first 150 words of the full text of this article appear below.

Osteoporosis is a skeletal disorder characterized by low bone mass and microarchitectural deterioration of bony tissue with a consequent increase in the risk of fracture. These fractures typically occur at the hip, spine and distal forearm; the annual cost attributable to them in England and Wales is £942 million, with over 90% of this figure ascribed to hip fracture [1]. The bone mass of an individual in later adult life depends upon the peak attained during skeletal growth and the subsequent rate of bone loss. Preventive strategies against osteoporosis may be aimed at either increasing the peak bone mass attained or reducing the rates of bone loss. There is evidence to suggest that peak bone mass is inherited, but current genetic markers are able to explain only a small proportion of the variation in individual bone mass or fracture risk [2]. It is likely that environmental . . . [Full Text of this Article]


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