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Rheumatology 2000; 39: 1425-1427
© 2000 British Society for Rheumatology

Letters to the Editor

The effects of dothiepin on subjects with rheumatoid arthritis and depression

A. J. Chuck, A. J. Swannell, A. O. House and R. Pownall

Department of Rheumatology, Dryburn Hospital, North Road, Durham DH1 5TW, UK

The first 10% of the full text of this article appears below.

SIR, We read with great interest the paper by Ash et al. [1], and would like to bring to readers' attention our own similar study, presented to the British Society of Rheumatology in 1989 [2].

One hundred and eighty-four patients with rheumatoid arthritis (RA), stable on second-line therapy, were screened for anxiety and depression using the Hospital and Depression scale (HAD); 91% (45%) met the entry requirements (HAD>7 on the subscales or >11 on the combined score), of whom 58 were recruited to receive dothiepin 75 mg or matched placebo for 6 weeks. Exclusions were as in the Ash et al. study, with . . . [Full Text of this Article]

G. Ash, C. M. Dickens1 and F. H. Creed1

Department of Psychiatry, Ormskirk & District General Hospital, Wigan Road, Ormskirk, Lancashire L39 2JW and
1 Department of Psychiatry, University of Manchester, Rawnsley Building, Manchester Royal Infirmary, Oxford Road, Manchester M13, UK


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