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Rheumatology 2000; 39: 1427-1428
© 2000 British Society for Rheumatology

Letters to the Editor

Diagnosis and therapy monitoring of Whipple's arthritis by polymerase chain reaction

P. Brühlmann, B. A. Michel and M. Altwegg1

Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland and
1 Medical Microbiology, University of Zurich, Zurich, Switzerland

The first 10% of the full text of this article appears below.

SIR, Whipple's disease is a multisystem bacterial infection usually characterized by malabsorption syndrome with diarrhoea and weight loss, low-grade fever and lymphadenopathy. Arthritis is often the first sign of Whipple's disease and may begin years before typical intestinal manifestations occur. Examination of joint fluid and tissue might therefore provide an opportunity for an early diagnosis. Diagnosis of Whipple's disease is usually established by the presence of periodic acid–Schiff (PAS)-positive, rod-shaped inclusions in macrophages of biopsies of the small bowel and other involved tissues and/or the identification of bacteria by electron microscopy. The non-cultivable Tropheryma whippelii has been identified by the polymerase chain reaction (PCR) . . . [Full Text of this Article]


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 J. Clin. Microbiol.Home page
R. C. Maibach, F. Dutly, and M. Altwegg
Detection of Tropheryma whipplei DNA in Feces by PCR Using a Target Capture Method
J. Clin. Microbiol., July 1, 2002; 40(7): 2466 - 2471.
[Abstract] [Full Text] [PDF]