Rheumatology 2000; 39: 353-359
© 2000 British Society for Rheumatology
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Systemic lupus erythematosus: a model for atherogenesis?
University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
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Introduction |
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Young women with systemic lupus erythematosus (SLE) have strikingly high rates of coronary heart disease [1–4]. Before we can solve the mystery of why these young women are so afflicted, we must first explore our understanding of cardiovascular disease in the general population. Only by coupling our knowledge of the pathogenesis of SLE and atherosclerosis and examining the risk factors common to both diseases can we begin to unravel the complexity of why these disease processes are so frequently linked.
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Epidemiology of cardiovascular disease in women |
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A great misperception is that death from cardiovascular disease is not a major health threat for women. On the contrary, cardiovascular disease, particularly coronary heart disease and stroke, is the leading killer of women in America. In recent years, it has accounted for nearly half of all deaths in women, more than all forms of cancer combined [5]. Significant ethnic differences exist in cardiovascular disease mortality,
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Potential risk factors for cardiovascular disease in SLE |
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Parallels between the pathogenesis of SLE and atherosclerosis |
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Chronic inflammation
Endothelial cell injury
Immune complexes.
CD40–CD40L interactions.
Autoantibodies.
Infectious agents.
Other sources of endothelial injury.
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Summary |
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Acknowledgments |
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Notes |
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References |
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