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Rheumatology 2000; 39: 1042-1044
© 2000 British Society for Rheumatology

Letters to the Editor

Fulminant alveolar haemorrhage in a case of recurrent small vessel vasculitis after renal transplantation

S. Blaschke, W. Grunewald, F. Strutz, B. Sattler1, G. A. Müller and M. Reuss-Borst

Department of Nephrology and Rheumatology and
1 Department of Pathology, University of Göttingen, Germany

The first 10% of the full text of this article appears below.

SIR, Systemic vasculitides are a heterogeneous group of diseases with varied and frequently overlapping modes of clinical manifestation. In this case report a severe form of recurrent polyangiitis overlap syndrome in a renal transplant recipient is presented. Despite initiation of combination therapy with cyclophosphamide and prednisolone, the disease course was complicated by rapid onset of fulminant alveolar haemorrhage, leading to the patient's death.

A 71-yr-old woman presented in March 1999 with a history of malaise, acute bronchitis, severe arthralgia and vasculitic skin rash over a period of several weeks. The patient's history revealed a similar episode of polyarthralgia and skin lesions in conjunction with acute renal failure in 1987. Histopathological examination of renal biopsy revealed a focal–segmental necrotizing vasculitis, but no deposits of immune . . . [Full Text of this Article]


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