Rheumatology 2000; 39: 939-949
© 2000 British Society for Rheumatology
Review |
Early inflammatory polyarthritis: results from the Norfolk Arthritis Register with a review of the literature. II. Outcome at three years
1 Withington Hospital, Manchester,
2 ARC Epidemiology Unit, University of Manchester Medical School, Manchester and
3 East Cheshire NHS Trust, Macclesfield, UK
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Introduction |
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This paper is the second in a series of two reviews which focus on the work of the Norfolk Arthritis Register (NOAR), a register of primary care-based inception cohort patients with inflammatory polyarthritis (IP). The first paper examined genetic and environmental risk factors for the development of IP and of its subset, rheumatoid arthritis (RA) [91]. This paper summarizes the outcome of those patients recruited in 1990–1993 and followed for 3 yr in terms of remission of synovitis, the development of physical disability and radiological erosions. We have also examined prognostic indicators. Most of these results have not been published previously and this is the first time we have looked at all three outcomes in the same group of patients. The NOAR data are presented in the context of a detailed review of previous studies of IP and RA.
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Background |
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The ability to predict disease outcome in patients newly
Previous prospective studies investigating predictors of outcome in early IP
NOAR study population used in this review
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Disease outcome at 3 yr in the NOAR cohort: frequency of occurrence and univariate associations |
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Remission of synovitis
Functional disability
Radiological damage
Overall disease outcome
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Predicting disease outcome using clinical variables measured at presentation: methodological issues |
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Study design
Definition of disease outcome
Methods of analysis
Validating the results
Selection of possible predictors
Presentation of the results
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Predicting outcome in the NOAR population using multiple logistic regression |
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A review of the influence of individual predictors on disease outcome |
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Demographic variables
Age.
Gender.
Disease duration at the time of presentation.
Clinical variables
Baseline HAQ score.
Rheumatoid factor.
Genetic factors
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Limitations of the NOAR study |
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Study population
X-ray data
Clinical and demographic data analysed
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Conclusions |
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